What are the reasons behind an unsuccessful IVF attempt?

What are the reasons behind an unsuccessful IVF attempt?


It is indeed very difficult for a woman to manage her emotions after an unsuccessful IVF attempt. But in any case, it does not mean that because the treatment failed this time, you are doomed to have unsuccessful attempts forever. In fact, there are couples who have made it through continuous attempts and who, if they had not tried again and again, would not have children today.

At Medimall, our goal after every unsuccessful attempt is to check again all the data that have come out of it, to extract every piece of information. Always keep in mind that even if the result is not what you wanted-we can still gather information that will help in any future attempts. Further testing is needed. Nothing in IVF is trivial. In general, the treatments used for most people are much the same. But success is hidden in the details. Often seemingly insignificant things come to the surface that are in fact important, even decisive for future success. Aligned with the doctor who performed your IVF and the rest of the team, we will advise you on the next steps to a success for you next attempt.

Factors that increase the risk of an IVF procedure

The age of the woman: A woman’s fertility declines from the age of 35 and much more so after 40. This means that she produces fewer eggs and/or her eggs are no longer of such good quality to easily lead to pregnancy. It is known that the incidence of chromosomal abnormalities increases as a woman gets older and embryos with chromosomal abnormalities are usually not implanted. Even embryos with normal genetic material that are created may be of substandard quality for which pregnancy is not achieved.

Embryo quality: The assessment of embryo quality is morphological and not based on objective criteria. The monitoring of embryo development in a non-invasive way, as well as the experience of embryologists, contribute to the selection of the best embryo! Poor embryo quality does not usually lead to pregnancy.

Thrombophilia: This is a disorder of blood clotting, which affects fertility. It is necessary to check in women who are trying to have a child without success, because if they have thrombophilia, embryo implantation may be prevented due to poor blood supply to the endometrium, which is the site of embryo implantation.

Antiphospholipid syndrome (APS): This syndrome is increasingly affecting women of childbearing age. Thus, women with APS have an increased tendency to develop poor endometrial perfusion which is the site of embryo implantation, and which may be responsible for failed IVF attempts or miscarriage.

Uterine abnormalities: Endometrial hypertrophy is affected by congenital uterine abnormalities, polyps, and fibroids. Hysteroscopic exploration of the uterine cavity and consolidation before IVF increases pregnancy rates. In any case, we consider it advisable after an unsuccessful IVF attempt, to perform diagnostic hysteroscopy in our clinic in combination with endometrial scratching and PRP. In case of adhesions or a polyp, the hysteroscopy has at the same time a therapeutic character as the adhesions is dissolved on the spot and the polyp is removed.

Immunological factors: Dysfunctions of the immune system can often be responsible for failed implants.

NK (Natural Killer) cells: ‘killer’ cells are a subgroup of lymphocytes, which protect the body against viruses and bacteria. The role of these cells in early pregnancy is not fully understood. They are present both in the uterine blood and in the endometrium (implantation site). Evaluation of NK cells in the blood and/or in the endometrium (biopsy) could be useful to distinguish this phenomenon as a cause of reproductive failure.

Psychology and timing

A key factor for a subsequent successful attempt is undoubtedly the psychology of the woman, which after an unsuccessful attempt is not good. You can certainly be supported by family and your own people, as well as your doctor. With proper support from them and with all the modern methods and tests at your disposal, we are optimistic that your dream can become true. If you really want it, don’t leave the time to pass. Unfortunately, time is not our best ally in these cases.

We are with you every step of the way.




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